Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
USERS' SCORE
Good
Based on 33 Reviews
8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
9
Acetyl-L-carnitine supports heart health
Our study focused on understanding how acetyl-L-carnitine affects heart disease, particularly in conditions of insulin-induced hypoglycemia. We found that when male rats were given acetyl-L-carnitine, it helped maintain normal blood pressure levels, preventing the spikes that occur with hypoglycemia. The supplement also decreased oxidative stress and inhibited markers of heart muscle thickening that usually arise during low blood sugar episodes. Overall, acetyl-L-carnitine appears to support heart health by providing energy and reducing harmful oxidative effects under stress.
Read More
9
AcCN aids aged hearts post-ischemia
We explored the effects of acetylcarnitine (AcCN) on aged hearts facing ischemia. In our study, older (24 months) and younger (6 months) rats were treated with AcCN before inducing ischemia and reperfusion.
The results showed that AcCN improved mitochondrial function, leading to better recovery from injury in older hearts. Aged hearts treated with AcCN exhibited less damage and functioned similarly to younger ones. However, AcCN didn’t seem to affect younger hearts.
Overall, this suggests that AcCN could be beneficial for preserving heart function in aging populations during ischemic events.
The results showed that AcCN improved mitochondrial function, leading to better recovery from injury in older hearts. Aged hearts treated with AcCN exhibited less damage and functioned similarly to younger ones. However, AcCN didn’t seem to affect younger hearts.
Overall, this suggests that AcCN could be beneficial for preserving heart function in aging populations during ischemic events.
Read More
8
We delved into how circulating levels of acylcarnitines, especially acetylcarnitine, relate to outcomes for patients with acute coronary syndromes (ACS). In a thorough multicenter study, we found that elevated acetylcarnitine levels can independently predict future cardiovascular risks, regardless of whether patients had diabetes. This finding highlights the importance of monitoring these metabolites as potential indicators to improve patient outcomes after ACS.
Read More
Most Useful Reviews
9
Energy boost noted
67 people found this helpful
I ordered carnitine for my 85-year-old mother, who had moderate Covid. Post-Covid, she had slight heart complications, fatigue, and memory issues. After taking carnitine, her energy and endurance increased, her blood pressure stabilised, and her memory fog cleared. We're delighted with the results.
Read More
9
Energy and heart support
51 people found this helpful
Acetyl-L-Carnitine is an ester form of L-carnitine, vital for vascular and heart issues, and it enhances cerebral circulation. It supports energy metabolism and overall well-being, particularly for the cardiovascular system. The supplement facilitates fatty acid transport into the mitochondria for energy production, thus aiding cellular needs. Moreover, it helps combat oxidative stress over time. Acetyl-L-Carnitine is beneficial for the nervous system, cognitive health, mood enhancement, and general wellness. It crosses the blood-brain barrier, elevating carnitine levels in the brain, which is essential for central nervous system ailments and mental fatigue. Daily intake suggested is three capsules on an empty stomach.
Read More
9
Supports heart health
6 people found this helpful
An excellent supplement for our heart muscle, myocardium. I recommend taking it on an ongoing basis throughout your life!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
- All Researches
9
Acetyl-L-carnitine supports heart health
Our study focused on understanding how acetyl-L-carnitine affects heart disease, particularly in conditions of insulin-induced hypoglycemia. We found that when male rats were given acetyl-L-carnitine, it helped maintain normal blood pressure levels, preventing the spikes that occur with hypoglycemia. The supplement also decreased oxidative stress and inhibited markers of heart muscle thickening that usually arise during low blood sugar episodes. Overall, acetyl-L-carnitine appears to support heart health by providing energy and reducing harmful oxidative effects under stress.
Read More
9
We investigated whether acetyl-L-carnitine (ALCAR) can shield hearts from damage caused by doxorubicin (DOX). In our study, we used Wistar rats divided into four groups to assess the effectiveness of ALCAR alongside DOX treatment.
Our findings showed that DOX significantly reduced heart function, while ALCAR preserved it. This indicates that ALCAR may protect against both functional and structural heart injury caused by DOX.
Our findings showed that DOX significantly reduced heart function, while ALCAR preserved it. This indicates that ALCAR may protect against both functional and structural heart injury caused by DOX.
Read More
9
AcCN aids aged hearts post-ischemia
We explored the effects of acetylcarnitine (AcCN) on aged hearts facing ischemia. In our study, older (24 months) and younger (6 months) rats were treated with AcCN before inducing ischemia and reperfusion.
The results showed that AcCN improved mitochondrial function, leading to better recovery from injury in older hearts. Aged hearts treated with AcCN exhibited less damage and functioned similarly to younger ones. However, AcCN didn’t seem to affect younger hearts.
Overall, this suggests that AcCN could be beneficial for preserving heart function in aging populations during ischemic events.
The results showed that AcCN improved mitochondrial function, leading to better recovery from injury in older hearts. Aged hearts treated with AcCN exhibited less damage and functioned similarly to younger ones. However, AcCN didn’t seem to affect younger hearts.
Overall, this suggests that AcCN could be beneficial for preserving heart function in aging populations during ischemic events.
Read More
8
We delved into how circulating levels of acylcarnitines, especially acetylcarnitine, relate to outcomes for patients with acute coronary syndromes (ACS). In a thorough multicenter study, we found that elevated acetylcarnitine levels can independently predict future cardiovascular risks, regardless of whether patients had diabetes. This finding highlights the importance of monitoring these metabolites as potential indicators to improve patient outcomes after ACS.
Read More
7
Acetyl L-Carnitine shows cognitive benefits
We evaluated how effective sequential therapy with levocarnitine and acetylcarnitine is for patients dealing with heart issues and moderate cognitive problems. In our study, 120 patients aged 54-67 were split into two groups: one received standard treatment plus the carnitines, while the other had just standard care.
Over 70 days, our findings revealed that this combination therapy may improve cognitive function and help with endothelial health. While patients tolerated the treatment well, it’s crucial to note that we did not observe significant benefits for heart disease outcomes specifically.
Over 70 days, our findings revealed that this combination therapy may improve cognitive function and help with endothelial health. While patients tolerated the treatment well, it’s crucial to note that we did not observe significant benefits for heart disease outcomes specifically.
Read More
User Reviews
USERS' SCORE
Good
Based on 33 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Energy boost noted
67 people found this helpful
I ordered carnitine for my 85-year-old mother, who had moderate Covid. Post-Covid, she had slight heart complications, fatigue, and memory issues. After taking carnitine, her energy and endurance increased, her blood pressure stabilised, and her memory fog cleared. We're delighted with the results.
Read More
9
Energy and heart support
51 people found this helpful
Acetyl-L-Carnitine is an ester form of L-carnitine, vital for vascular and heart issues, and it enhances cerebral circulation. It supports energy metabolism and overall well-being, particularly for the cardiovascular system. The supplement facilitates fatty acid transport into the mitochondria for energy production, thus aiding cellular needs. Moreover, it helps combat oxidative stress over time. Acetyl-L-Carnitine is beneficial for the nervous system, cognitive health, mood enhancement, and general wellness. It crosses the blood-brain barrier, elevating carnitine levels in the brain, which is essential for central nervous system ailments and mental fatigue. Daily intake suggested is three capsules on an empty stomach.
Read More
9
Supports heart health
6 people found this helpful
An excellent supplement for our heart muscle, myocardium. I recommend taking it on an ongoing basis throughout your life!
Read More
9
Positive heart effects
2 people found this helpful
I have been taking this form of carnitine from "now brands" with coenzyme Q10 for three years. My doctor confirms that my heart sounds very good, which must indicate it works well.
Read More
0
Cautiously effective
If you have any inflammatory conditions, be very cautious. I don't doubt the brand or quality, but I have Long Covid and took this for fatigue. Within three days, I experienced heightened fatigue and severe heart palpitations. I continued for a few more days, which worsened my symptoms, especially the heart palpitations. After stopping, I returned to normal within days. If you have pre-existing conditions, proceed carefully and don't exceed 1g per day at first.
Read More
Frequently Asked Questions
7.5
Increased energy
I took it for heart support, prescribed by my family doctor following Covid. I’ve definitely gained energy and feel stronger since starting it.
7.5
Maintains heart health
3 people found this helpful
This supplement is crucial for maintaining heart health and aids in fat loss. I noticed significant changes after finishing my first pack and now am on my second. Consulting a doctor is advisable, as individual responses can vary.
9
Blood pressure drop
Good value for money! Given my family history of cerebrovascular diseases, I continue taking this as a preventative measure. Along with vitamin E, my blood pressure has dropped from 160 to 120 after three months of use.
9
Energy boost noted
67 people found this helpful
I ordered carnitine for my 85-year-old mother, who had moderate Covid. Post-Covid, she had slight heart complications, fatigue, and memory issues. After taking carnitine, her energy and endurance increased, her blood pressure stabilised, and her memory fog cleared. We're delighted with the results.
8
Great heart support
10 people found this helpful
The best Acetyl L-Carnitine I've tried, although a bit pricey. I typically take six capsules before workouts, or three in the morning for heart support. It works wonderfully, enabling me to run effectively and engage in intense cardio for extended periods.
7.5
Memory and focus boost
5 people found this helpful
Acetyl-L-carnitine offers numerous benefits, including reducing fat cells and lowering risks associated with Alzheimer’s and Parkinson’s diseases. It enhances memory retention and attention, particularly useful in tackling memory disorders, while providing an energy boost, especially beneficial before workouts.
0
Cautiously effective
If you have any inflammatory conditions, be very cautious. I don't doubt the brand or quality, but I have Long Covid and took this for fatigue. Within three days, I experienced heightened fatigue and severe heart palpitations. I continued for a few more days, which worsened my symptoms, especially the heart palpitations. After stopping, I returned to normal within days. If you have pre-existing conditions, proceed carefully and don't exceed 1g per day at first.
9
Positive heart effects
2 people found this helpful
I have been taking this form of carnitine from "now brands" with coenzyme Q10 for three years. My doctor confirms that my heart sounds very good, which must indicate it works well.
9
Energy and heart support
51 people found this helpful
Acetyl-L-Carnitine is an ester form of L-carnitine, vital for vascular and heart issues, and it enhances cerebral circulation. It supports energy metabolism and overall well-being, particularly for the cardiovascular system. The supplement facilitates fatty acid transport into the mitochondria for energy production, thus aiding cellular needs. Moreover, it helps combat oxidative stress over time. Acetyl-L-Carnitine is beneficial for the nervous system, cognitive health, mood enhancement, and general wellness. It crosses the blood-brain barrier, elevating carnitine levels in the brain, which is essential for central nervous system ailments and mental fatigue. Daily intake suggested is three capsules on an empty stomach.
9
Cardiovascular improvement
1 people found this helpful
I researched different forms of carnitine and chose acetyl L-carnitine as it’s especially suited for older individuals alongside vitamins. This form effectively crosses the barrier between the circulatory and central nervous systems, enhancing both brain and cardiovascular function, vital for heart energy. I prefer lower dosages, opting for 500 mg, and am pleased with my decision.
6
Better heart function
I bought this for my mum, as her doctor recommended it for improved heart function. She has noticed a positive impact, enhancing her overall health.
9
Acetyl-L-carnitine supports heart health
Our study focused on understanding how acetyl-L-carnitine affects heart disease, particularly in conditions of insulin-induced hypoglycemia. We found that when male rats were given acetyl-L-carnitine, it helped maintain normal blood pressure levels, preventing the spikes that occur with hypoglycemia. The supplement also decreased oxidative stress and inhibited markers of heart muscle thickening that usually arise during low blood sugar episodes. Overall, acetyl-L-carnitine appears to support heart health by providing energy and reducing harmful oxidative effects under stress.
9
We investigated whether acetyl-L-carnitine (ALCAR) can shield hearts from damage caused by doxorubicin (DOX). In our study, we used Wistar rats divided into four groups to assess the effectiveness of ALCAR alongside DOX treatment.
Our findings showed that DOX significantly reduced heart function, while ALCAR preserved it. This indicates that ALCAR may protect against both functional and structural heart injury caused by DOX.
Our findings showed that DOX significantly reduced heart function, while ALCAR preserved it. This indicates that ALCAR may protect against both functional and structural heart injury caused by DOX.
2
We explored whether L-carnitine, a compound considered for heart disease prevention and treatment, is truly effective. Using Mendelian randomization, we analyzed genetic data to understand its impact on conditions like coronary artery disease, heart failure, and other risk factors.
Our findings reveal that L-carnitine offers no significant benefits. In fact, it may even pose risks for heart health. Additionally, we noted that its effects could vary by sex, highlighting the need for further research into these differences and the mechanisms behind them.
Our findings reveal that L-carnitine offers no significant benefits. In fact, it may even pose risks for heart health. Additionally, we noted that its effects could vary by sex, highlighting the need for further research into these differences and the mechanisms behind them.
7
Acetyl L-Carnitine shows cognitive benefits
We evaluated how effective sequential therapy with levocarnitine and acetylcarnitine is for patients dealing with heart issues and moderate cognitive problems. In our study, 120 patients aged 54-67 were split into two groups: one received standard treatment plus the carnitines, while the other had just standard care.
Over 70 days, our findings revealed that this combination therapy may improve cognitive function and help with endothelial health. While patients tolerated the treatment well, it’s crucial to note that we did not observe significant benefits for heart disease outcomes specifically.
Over 70 days, our findings revealed that this combination therapy may improve cognitive function and help with endothelial health. While patients tolerated the treatment well, it’s crucial to note that we did not observe significant benefits for heart disease outcomes specifically.
References
- Davies A, Wenzl FA, Li XS, Winzap P, Obeid S, et al. Short and medium chain acylcarnitines as markers of outcome in diabetic and non-diabetic subjects with acute coronary syndromes. Int J Cardiol. 2023;389:131261. 10.1016/j.ijcard.2023.131261
- Statsenko ME, Turkina SV. [Antiastenic effect of sequential levocarnitine and acetylcarnitine therapy in patients with cardiovascular diseases]. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122:95. 10.17116/jnevro202212212195
- Zhao JV, Burgess S, Fan B, Schooling CM. L-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study. BMC Med. 2022;20:272. 10.1186/s12916-022-02477-z
- Statsenko ME, Turkina SV. [Possibilities of sequential levocarnitin and acetylcarnitin treatment in correcting cognitive deficiency in patients with cardiovascular diseases]. Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121:45. 10.17116/jnevro202112105145
- Israr MZ, Bernieh D, Salzano A, Cassambai S, Yazaki Y, et al. Association of gut-related metabolites with outcome in acute heart failure. Am Heart J. 2021;234:71. 10.1016/j.ahj.2021.01.006
- Alanazi WA, Al-Harbi NO, Imam F, Ansari MA, Alhoshani A, et al. Role of carnitine in regulation of blood pressure (MAP/SBP) and gene expression of cardiac hypertrophy markers (α/β-MHC) during insulin-induced hypoglycaemia: Role of oxidative stress. Clin Exp Pharmacol Physiol. 2021;48:478. 10.1111/1440-1681.13455
- Dundar HA, Kiray M, Kir M, Kolatan E, Bagriyanik A, et al. Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats. Arch Med Res. 2016;47:506. 10.1016/j.arcmed.2016.11.008
- Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, et al. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Free Radic Biol Med. 2012;53:216. 10.1016/j.freeradbiomed.2012.03.016
- Sang Y, Zhou LJ, Jing L, Yuan L, Lu LX, et al. [Roles of PYK2 and caveolin-1 in alcoholic cardiomyopathy and the effect of drug intervention]. Zhonghua Yi Xue Za Zhi. 2011;91:1561.
- McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, et al. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens (Greenwich). 2007;9:249.
- Lesnefsky EJ, He D, Moghaddas S, Hoppel CL. Reversal of mitochondrial defects before ischemia protects the aged heart. FASEB J. 2006;20:1543.
